Beilstein J. Org. Chem.2023,19, 399–427, doi:10.3762/bjoc.19.31
Jorge de Lima Neto Paulo Henrique Menezes Universidade Federal de Pernambuco, Departamento de Química Fundamental, Recife-PE, 50740-560, Brazil 10.3762/bjoc.19.31 Abstract The combretastatinD series and its analogues, corniculatolides and isocorniculatolides belong to a class of macrocycles
called cyclic diaryl ether heptanoids (DAEH). This review is intended to highlight the structure elucidation, biosynthesis, and biological activity of these compounds as well as the use of different strategies for their synthesis.
Keywords: combretastatinD; corniculatolide; isocorniculatolide
stereochemical characteristics, but also for shown biological activities, with potential therapeutic application [6][7][8][9][10][11][12]. Examples of this class of compounds are the combretastatinD series [13] and their analogues, corniculatolides and isocorniculatolides [14], which are structurally
PDF
Graphical Abstract
Figure 1:
Structures of some members of the combretastatin D series, corniculatolides, and isocorniculatolide...